Christina Applegate is departing her NBC comedy, "Up All Night.""It's been a great experience working on 'Up All Night', but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors," Christina said in a statement on Friday. "Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always."
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